Is muscimol legal? Muscimol is a psychoactive agent which occurs naturally in Amanita muscaria mushrooms. The legal status of muscimol varies from country to country and cannot easily be established through international drug classifications. In general, muscimol is not listed as an illegal substance in its own right in most places, although the mushrooms that contain it may be subject to regulation, restriction, or even discouragement from sale and consumption because of safety issues. In the United States, muscimol is not scheduled at a national level, although substances containing the active ingredients may be examined if they are designed for human consumption. Other jurisdictions have different laws regarding psychoactive mushrooms, and there is no clear standard on whether or not these products should be legalized. It is therefore essential to establish the applicable regulations in each place prior to engaging in any purchase related to these substances.